Sebastien Boridy.

Background
Sebastien is a native of Montreal and graduated from McGill with a Bachelor’s of Science, majoring in Biochemistry, with a minor in Pharmacology. Outside of the lab, he enjoys playing rubgy, keeping fit, and cooking.

Research highlight
Sebastien’s work is focused on characterizing the interactions of nanoparticle-based drug delivery systems with brain cells. More specifically, he is looking at the use of celastrol-based nanomedicines, both polymeric and metallic, for the treatment of chronic neuro-inflammation and glioblastomas.

Fellowships & awards

1.   Vanier Canada Graduate Scholarship by Canadian Institutes of Health Research (CIHR)

Publications

1. Modulation of inflammatory signaling and cytokine release from microglia by celastrol incorporated into dendrimer nanocarriers. Boridy S, Soliman GM, Maysinger D. Nanomedicine (Lond). 2012 Aug;7(8):1149-65.
2. A novel mouse model of Alzheimer's disease with chronic estrogen deficiency leads to glial cell activation and hypertrophy. Prat A, Behrendt M, Marcinkiewicz E, Boridy S, Sairam RM, Seidah NG, Maysinger D. J Aging Res. 2011;2011:251517.
3. Subcellular Fate of Nanodelivery Systems (Ch.6:93-121). Maysinger D, Boridy S, Hutter E. in Organelle-Specific Pharmaceutical Nanotechnology (V. Weissig and G. D’Souza eds.), Wiley & Sons Inc. (2010)
4. Microglial response to gold nanoparticles. Hutter E, Boridy S, Labrecque S, Lalancette-Hébert M, Kriz J, Winnik FM, Maysinger D. ACS Nano. 2010 May 25;4(5):2595-606.
5. The binding of pullulan modified cholesteryl nanogels to Abeta oligomers and their suppression of cytotoxicity. Boridy S, Takahashi H, Akiyoshi K, Maysinger D. Biomaterials. 2009 Oct;30(29):5583-91.
6. Molecular imaging of lipid peroxyl radicals in living cells with a BODIPY-alpha-tocopherol adduct. Khatchadourian A, Krumova K, Boridy S, Ngo AT, Maysinger D, Cosa G. Biochemistry. 2009 Jun 23;48(24):5658-68.